Cannabinoids and the Immune System: Immuno-Cannabinoid Effects

“That was something I could help with,” Keen said. In addition, the concentration of pro-carcinogens such as benz-[α]-anthracene and benzo-[α]-pyrene are up to twofold higher in marijuana tar (3,7). In addition, secretion of the Th1/Th17-promoting IL-12 and IL-23 cytokines was also increased in CB 2 −/− BM-DCs, and CD4+ T cells of the KO mice showed an enhanced capacity to differentiate into interferon (IFN)-γ- or IL-17-producing effector cells, altogether suggesting that CB 2 may be a potential therapeutic target in the clinical management of host-versus-graft reactions (61). Arbonne essentials review, arbonne’s Lip Save Sunscreen provides active ingredients like chamomile and linden extracts to help moisturize and protect lips. Initially CBD-induced apoptosis in T cells was described in Jurkat and MOLT4 human T cells. Knowing that a major research university was just 30 miles north of the VSU campus, Keen started his search for collaborators on Virginia Commonwealth University’s website.

THC and another ingredient called cannabidiol (CBD) are the main substances of therapeutic interest. For more on this topic, please see Donald P. Immune system, we evaluate HAD under 14. In the brain, when the psychoactive component THC links up with CB1, it slows down or blocks the release of a variety of neurotransmitters—signaling molecules released by neurons—including glutamate and dopamine. Moreover, mostly, but not exclusively because of its potent analgesic actions, it was considered to be beneficial in the management of several diseases (19, 42, 43). It should also be noted that there are several reports suggesting that CBD acts as an allosteric modulator of CB 1 or CB 2 receptors,61–64 although the role for CB 1 or CB 2 receptor allosteric modulation by CBD in immune function has not yet been determined. Conducted at the Rambam Medical Centre in Haifa, Israel, patients taking medical cannabis alongside the immunotherapy cancer drug Nivolumab responded 50% less compared to those on immunotherapy alone.

The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler’s murine encephalomyelitis virus by a receptor-mediated pathway.

In self-quarantine because of coronavirus? For those familiar with cannabinoids, their fascinating interactions with the human body are probably old news. Shi Y, Duan Y-H, Ji Y-Y, Wang Z-L, Wu Y-R, Gunosewoyo H, et al. The study also noted that the reported anti-inflammatory effects of cannabis were greatly attenuated when body weight is controlled for and suggests that the inverse cannabis-body weight association might explain the lower levels of circulating inflammatory biomarkers in adult cannabis users. Immune system and chronic diseases, when a person infected with HIV has a CD4 cell count that is below 200 cells per millimeter they are defined as having AIDS. In this article, we explore some of the most relevant research publications on CBD’s far-reaching influence on the immune system.

  • Other studies suggest that cannabis does something else entirely, making our immune systems stronger and helping it battle infections.
  • But researchers are struggling to understand exactly how.
  • There’s no hard and fast rule why it appears, but most cancers share the same mechanism.
  • The concept that dysregulation of the ECS can play a role in autoimmune diseases is supported by several lines of evidence.
  • 125,132 Together, the results suggest that CBD's mechanism for neutrophil suppression involves both decreased numbers of neutrophils and compromised MPO activity.

Contact a Marijuana Doctor or Dispensary for More Information

Cannabis is an extremely versatile plant, but it all comes down to each patient’s unique situation. According to the NIDA, there may be an association between marijuana use and some mental health disorders like depression and anxiety. Endocannabinoids and the immune system in health and disease. The study is published in the December issue of the European Journal of Immunology. Janus kinase inhibition for immunosuppression in solid organ transplantation: By contrast, the investigations into the effects of cannabis or cannabinoid-based therapeutics on immunity in human subjects are quite limited.

Why Are There Different Opinions On The Relationship Between Cannabis And The Immune System?

Blood infections are rare but life-threatening. Cannabis is gaining attention in the medical world for its ability to slow the progression of autoimmune disorders. The importance of a balanced immune response, doctors are also learning more about how to balance the benefits of immunotherapy drugs, which were once off limits to cancer patients with autoimmune disease. It is important to recognize that these immunomodulatory effects are the result of a coordinated cascade of responses from the so-called “innate immune system” as well as the “adaptive immune system. Br J Pharmacol (2020) 171: However, studies on the subject have had mixed results. Interestingly, the ECS and cannabinoids have been shown to play a key role in “balancing” the various arms and components of the immune system. Cannabinoid neuroimmune modulation of SIV disease. However, a few studies conducted without federal backing show promising results when it comes to marijuana and your immune system.

Fourth, increasing our understanding of CBD's effects in response to a variety of immune stimuli and degrees of immune stimulation will help in interpreting effects of CBD in humans and other outbred species that are naturally exposed to a variety of pathogens.


Studies involving animals showed that THC might damage the immune system, making you more vulnerable to illnesses. Marijuana is made from the shredded and dried parts of the cannabis plant, including the flowers, seeds, leaves, and stems. Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis. 3 months Male C57BL/6 mice Streptozotocin-induced diabetes i. Drink these 8 teas to boost immune system and reverse illnesses. Conversely, marijuana has also been used to ease symptoms of nausea or upset stomach. 58 Similarly, CBD inhibited interleukin (IL)-1 in a hypoxia-ischemia brain insult model and this effect was reversed with the CB 2 receptor antagonist, AM630. “Marijuana cannabinoids present us with a double-edged sword,” Nagarkatti said. It may heighten your sensory perception and your perception of time.

Due to their well-described anti inflammatory effects, pCBs are also potential candidates to improve therapeutic protocols of transplantation (60).

Without being exhaustive, in a Wistar rat model of pneumococcal meningitis, CBD (10 mg/kg, i. )Generally speaking, there are two different ways in which the body’s adaptive immune cells can seek out and “eliminate” dangerous pathogens (foreign agents that can result in disease, infection, etc): Ligresti A, De Petrocellis L, Di Marzo V. Keeping your immune system healthy is a way to keep the flu bug away. J Pharmacol Exp Ther 323, 675-683 (2020). Medical cannabis is a well-established palliative treatment for HIV thanks to the plant’s ability to reduce anxiety, improve appetite, and ease pain. More research is needed. According to another EAE study, in which CBD was applied after the development of the disease, CBD (10 mg/kg mouse, i. )And of course, there is the question of whether consuming cannabis for its anti-inflammatory properties would be of benefit to a healthy individual.

Immunotherapy for Cancer

Previous studies have hinted at immune system abnormalities among cannabis users -- specifically, in the function of immune system cells called T lymphocytes and natural killer cells. Humoral immunity complements the cell-mediated system by using B-cells and developing antibodies to neutralize antigens or pathogens that are recognized as foreign. As outlined above, in the T cell section, in vitro CBD treatment of MOG 35–55 -specific T cells co-cultured with APCs with CBD suppressed IL-17A and IL-6 production, suggesting CBD suppressed TH17 development; however, production of Il10 mRNA was potentiated with CBD treatment, suggesting that CBD may have multiple suppressive mechanisms. Scott, Angus G. The study highlights how cannabis is able to mediate its effects through the cannabinoid-1 (CB1) and cannabinoid-2 (CB2) receptors. There is a need for more large-scale, scientific studies of medical cannabis.