Marijuana Effects on the Immune System

Marijuana researchers have found enough evidence over the past few decades that they now deem cannabis as a safe product to use, even while using most other types of medications. As the "enhancement smoker" played by Jon Stewart in Half Baked immortally described, every experience is different on weed. An inflammatory response acts as the body’s defence mechanism in case of infection or damage. ” This is considered a benefit for people being treated with chemotherapy for cancer.

What is medical marijuana?

And while this is good for relieving pain, it’s not necessarily good for your immune system. CBD is believed to regulate the metabolism of THC by inactivating cytochrome P450, an important class of enzymes that metabolize drugs. Want to prevent colds? have sex weekly, one 10-year study of 1,500 people over 70 years old found those with stronger friendship networks lived longer than those with fewer friends. Holistic approaches for autoimmune conditions are to decrease inflammation, repair the digestive tract, and regulate the immune system.

Smoking a bowl is usually a fine way to improve your mood and may seem like a way for your friend to diminish his misery when he's achy, stuffed-up, nauseated and stuck at home. Within minutes, your heart rate may increase by 20 to 50 beats per minute. Br J Sports Med.

What kind of damage does weed do to your lungs—especially if you smoke daily?

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You may be less aware that alcohol also damages your immune system, increasing your risk of potentially fatal illnesses such as pneumonia. Most studies of the effects of medical marijuana on people with diseases like Parkinson’s disease, multiple sclerosis, and Crohn’s disease have been small group trials or interviews of patients using medical marijuana. In mice, infection with influenza leads to lethargy, anti-social behavior, and weight loss, but recovery usually happens within a week or two because high numbers of macrophages and T cells are able to fight off the virus in the lungs. For this reason, people with HIV/AIDS’ response to cannabis suggests how everyone’s body interacts with cannabis. Different methods of taking the drug may affect your body differently. A precise quantity of cannabinoids to be ingested can be advised only if taking into account what’s troubling you personally. In persons not accustomed to smoking weed, marijuana usage does lead to a slight, temporary decrease in testosterone production levels. NHANES examination weights that account for the unequal probabilities of selection, oversampling and non-response were applied to all analyses and standard errors were estimated using the Taylor series linearization method.

Another adverse effect of great importance lurking chronic cannabis users is the consequence anatomical changes, a 2020 meta-analysis concluded that chronic cannabis consumption results in reduction of hippocampal grey mater39. There’s a deficit of marijuana research due to government agencies hesitancy or downright opposition to cannabis research. Human BMVEC isolated from eleptogenic patients were activated using TNF-α to evaluate consequent gene expression.

Under federal law, marijuana manufacture, distribution, and consumption are illegal.

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The adaptive immune system has two key mechanisms: In such cases, suppressing the natural immune response and decreasing inflammation therein could potentially make things worse. Now, before we get into the specific effects of THC on muscle growth, it bears mentioning that there’s not a wealth of information on the subject matter. Does your child have a cold? But the benefits can also include things that are simply felt or perceived, without being measurable. Once induced and activated, CB2 receptor decreased leukocyte adhesion, prevented up regulation of adhesion molecules, promoted 2.

Despite cannabis having the ability to suppress the immune system in healthy individuals, recent research suggests that it can actually strengthen the immune response in individuals with a weakened immune system. It has already been granted orphan drug status—a path to approval based on smaller clinical studies than normal—by the Food and Drug Administration. There is not much research into the effects of secondhand marijuana smoke. Unfortunately, lack of clinical data prevents a definitive conclusion. When you come down from the high, you may feel tired or a bit depressed. Winters KC, Lee C-YS.

Although more research is needed here, the preliminary results look promising. Ways to boost your immune response and fight disease, while it's used in many sweet desserts, ginger packs some heat in the form of gingerol, a relative of capsaicin. As you may remember, the endocannabinoid system, or ECS, is a network of cannabinoids and receptors that works to regulate most functions in the human body. Medical cannabis is a well-established palliative treatment for HIV thanks to the plant’s ability to reduce anxiety, improve appetite, and ease pain. The effects of cannabinoids on hematopoiesis, and immune cell proliferation using animal and cell based models has been widely demonstrated and a number of studies have examined the association of cannabis use and white blood cell counts in human immunodeficiency virus (HIV). Marijuana is a controversial subject–it is illegal according to federal law, even while 29 states (and Washington, DC) have legalized medical use in some form or another. Cannabis is a unique biphasic botanical remedy that can bring the system back into balance in numerous regards. ‘Research on heavy cannabis use and cardiovascular health is needed as systemic inflammation, increased cardiovascular risk and increased mortality risk have been all associated with white blood cell elevation within the normal physiologic range.

Under the Controlled Substances Act, marijuana is a Schedule I drug, which reflects the federal government’s position that this drug has no medical utility.

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These medications may make someone more susceptible to infection, and may lead to the development of cancer. One aspect that differentiates these conditions from the ones I previously mentioned is a severe drop in the overall immune capacity. Therefore, people may consume more to feel the effects faster, leading to dangerous results.

At this point of preliminary research involving cannabis’ effects on the immune system, it is still too early to make a general statement whether it is wholly “good” or “bad” for immune health. However, in regular tokers, weed seems to have little-to-no impact on testosterone levels. Theiler's Murine Encephalomyelitis Virus. In this article we aimed to review the laboratory and clinical evidence regarding Medical Cannabis and neurological autoimmunity diseases. Smoking destroys our oral immune system, 14, 261–262 (1999). In other words, THC and CBD suppress the immune system’s ability to work properly, so the foreign invader has an advantage. One of the most deleterious effects of long-term weed use is loss of memory.

Not all Cannabis Research Is Promising

These rogue bacteria can cause inflammation in the liver and may lead to liver damage. 8 vitamins & minerals you need for a healthy immune system – health essentials from cleveland clinic. The study failed to prove the beneficial outcome of dronabinol use in two main outcomes (time to confirmed EDSS [Extended Disability Status Scale] score progression and change in MSIS-29 [Multiple Sclerosis Impact Scale-29] score). Thank goodness we have an immune system: Conditions like arthritis or multiple sclerosis involve an overactive immune system, but there are other conditions where the body’s immune functions may have declined and are too weak, as is the case with HIV/AIDS and cancer. Naproxen and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that can be prescribed but come with a list of side effects like stomach ulcers, high blood pressure, kidney or liver problems, and dizziness and headaches. It's as if you're hitting mute on the alarm, but the alarm is going off for a reason.

Your doctor will also need to regularly monitor things like your: The coherence of the above mentioned experiments is also exemplified at the genetic level. 13 vitamin e, vitamin c, and immune response: recent advances, this is not an indication of a security issue such as a virus or attack. Now here’s where the problem lies. An increase in your appetite is common when taking any form of marijuana, leading to what many call “the munchies.

Puighermanal, E. Research also shows that being properly vaccinated has a positive effect on the immune system. Little is known about what causes the body to attack itself – possibly a combination of genetic tendencies and environmental toxins or viruses. AI can remain latent in the body, resulting in ailments that have not been properly pinpointed. Coping with an autoimmune disease may feel burdensome, but it can also be an opportunity to get back in touch with your body.


It links THC to higher production of CD4 and CD8 cells in monkeys. The blood-brain-barrier (BBB) as well as the blood-spinal cord-barrier (BSCS) and their disturbance is often postulated as a possible mechanism of pathogenesis in neurological autoimmune disease. If you take this test and it comes back positive, it likely indicates you have an autoimmune disease.

Cannabinoids and the immune system: No matter how you use marijuana, the drug can cause immediate and long-term effects, such as changes in perception and increased heart rate. Concentrations of delta9-tetrahydrocannabinol and 11-nor-9-carboxytetrahydrocannabinol in blood and urine after passive exposure to Cannabis smoke in a coffee shop. (1) lymphocytes (B cells and T cells) that destroy antigens and help the body to remember previous attackers; and 2) phagocytes that absorb and neutralize foreign intruders. THC and another ingredient called cannabidiol (CBD) are the main substances of therapeutic interest. In the United States, marijuana use has increased over the last several years as many states have voted to legalize it for medical use and/or decriminalize (or outright legalize) it for recreational use. When mice are treated with THC while infected with influenza, the number of macrophages and T cells traveling to the lungs to fight off the virus is reduced, and recovery takes longer (4).

Breathing problems. I should also add that in making these observations, I have concentrated on the risks of smoking natural marijuana, since it is the most effective method of ingesting its active cannabinoids. So, what about the relationship between marijuana and lupus?

Cannabis & the Immune System

Some of the symptoms medical marijuana for autoimmune disease can help treat include: There’s a lot of talk regarding inflammation these days, especially with regard to chronic disease. The aim should be to modulate the immune system and bring it back into balance, not to turn it off completely. An imbalance between cell mediated and humoral immunity results in disease. However, the states do not need to follow the government’s lead. While inflammation has a bad reputation, no human would be able to survive without it. Treats anxiety, depression, nausea, inflammation, stress, pain and helps with creativity, focus and energy. Blood – spinal cord – barrier; TNF-α :

Their study included the pain-relieving compound delta-9 tetrahydrocannabinol (THC). If you’re a regular smoker, you’re more likely to wheeze, cough, and produce phlegm. Muscle spasms and stiffness caused by multiple sclerosis. Other autoimmune diseases can attack your entire body — like lupus. The study also noted that the reported anti-inflammatory effects of cannabis were greatly attenuated when body weight is controlled for and suggests that the inverse cannabis-body weight association might explain the lower levels of circulating inflammatory biomarkers in adult cannabis users. Hashimoto's diet: intermittent fasting for your thyroid health — boost thyroid: hashimoto's and hypothyroid app. The following article discusses some of the potential benefits and side effects that marijuana has on the body. It’s now being seen as a supplement that can help fight the common cold and other illnesses that tend to crop up during the colder months. 1007/s13181-015-0501-0.

  • The immune system may be harmed directly by intoxicating substances, or the way the drug is ingested may contribute to a higher risk of infection, coupled with a lower immune response.
  • Cannabinoids protective effect goes beyond the BBB and also extends to the BSCB.
  • For example, some cells of the immune system (white blood cells such as macrophages and T cells) detect foreign invaders of your body (e.)


Bell C, Slim J, Flaten HK, Lindberg G, Arek W, Monte AA. Yet again, this is an area in dire need of further research. Foods to boost the immune system, try to get plain yogurts rather than the kinds that are preflavored and loaded with sugar. Impact of adolescent marijuana use on intelligence:


Check with local laws regarding living wills and the use of medical marijuana before proceeding. Cannabis is already able to treat achy muscles, fatigue, swelling, anxiety, and more. Another potential mechanism can be through the effect of cannabinoids on stem cells. CBD has natural antibacterial properties which can help fight against secondary bacterial infections that may develop from the cold and flu. Fast forward to the 21st century. THC and CBD should be used together for most disorders treatable by cannabis because they interact with each other and terpenes, maximizing their therapeutic potential in what’s colloquially known as the entourage effect. The bulk of immune system-related research looks at cannabis’ effect on HIV/AIDS patients. It is possible that by replacing missing endocannabinoids, the cannabidiol in medical marijuana helps to restore the balance of the immune system.

The primary autoimmune disease treatment is inflammation-reducing medications and medications to help to calm down an overactive immune response. Autoimmune conditions are an area of medicine that remain largely misunderstood. Department of paediatrics, ~ Then tested the cytotoxic activity of spleen cells restimulated, but ~ n observed no cytolytic activity Specifically expensive mice immunized with ~ ~ z ~ 0 ~ dendritic cells unstimulated (hIS- ~ C). A hybrid can do some of both, depending how much of one strain or another is in its genes. This causes the "high" that people feel. Cancer patients have more of these cells than healthy people.